I wish I could site articles and research for my belief about this, but I can't. But here is my opinion based upon personal experience and observation.
From what I've read of studies of how girls in playgroups relate at young ages vs how boys playgroups relate, I've concluded that the identity of a girl is developed by verbal interaction and reflection within the group, whereas for boys, identity is developed through active interaction and reflection. From what reading I've done I'm pretty convinced that I could find research to show that statistically, females have a greater need for intimacy within their peer group, and a greater intimacy as well, in order to be happy, than do males. Statistically.
If isolation is defined purely as lack of intimacy, then some conclusion regarding greater harm to females might be drawn. But isolation might not be defined that way. Also, your question is about being hurt on a deeper level, and I don't know how that deeper level could be quantified.
My standard rant is that one man one woman is the stupidest way to arrange society, that women and children should operate as a collective, and men should operate as a collective. Women in the center of the wheel, men encircling. I don't push this view on anyone else, though, and my own life doesn't look anything like this. I can't see it being possible in this modern world. I'm being prehistoric, I think.
OK, I had to come back and modify this because - I really don't care about the division of men and women, so much as that there be a natural place for those who operate relationally and those who operate "actionally".
I conclude by confessing that it has taken me decades to learn to have a talking friendship. I tend toward action-relating, and I am having a lonely life.